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Title
[BK21 seminar] 30th June(Thu) Wonmuk Hwang(Texas A&M University) "Mechanics and Dynamics of Immune Receptors"
Date
2022.06.29
Writer
기계공학부
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Please give a lot of attention and participation from the members of the Mechanical Engineering department.


▣ TitleMechanics and Dynamics of Immune Receptors

▣ Speaker황원묵 교수

▣ Affiliation: Department of Biological Engineering, Texas A&M University

Date: 2022. 6. 30.(목) 10:00

Venue: 제4공학관 D404호  

Host: 이형석 교수

▣ Abstract

The αβT-cell receptor (TCRαβ) recognizes 8-10~aa antigenic peptide loaded on the major histocompatibility complex (pMHC) molecule with exquisite sensitivity, with a signal-to-noise ratio of 1 in 105. Yet, the equilibrium binding affinity of cognate and non-cognate pMHCs are similar and weak, on the order of micromolar range. Recent experimental findings suggest that application of physiological-level picoNewton forces to the TCRαβ-pMHC complex increases the bond

lifetime in ligand-dependent manner. This suggests that TCRαβ-pMHC system exhibits catch bond behavior that mechanically enhances antigen discrimination. We address the atomistic mechanism for the activation of the catch bond by performing all-atom molecular dynamics simulation of TCRαβ-pMHC complexes under picoNewton forces and their variants. By comparing subdomain motion and dynamics of interfacial contacts, we find that the applied load suppresses certain modes of domain

motion that have destabilizing effect on the TCRαβ-pMHC interface in the absence of load. The dynamical activation of catch bond also allows for allosteric control of the interface by altering the motion of distal domains. The dynamical mechanism also has implications in other types of T-cell receptors.


Attachments
20220630_BK21_황원묵 교수(이형석 교수님).jpg