기계공학부 구성원들의 많은 관심과 참여 부탁드립니다.

▣ 주 제:  3D Nanoplasmonic Materials for Sensitive Biosensing Applications

▣ 연 사:  박성규 박사

▣ 소 속:  한국재료연구원

▣ 일 시:  2024. 8. 21.(수) 16:00

▣ 장 소:  제4공학관 D404호

▣ 초 청: 정효일 교수

▣ 초 록

Surface-enhanced Raman spectroscopy (SERS) is a promising analytic tool for the identification of chemical and biomedical specimens owing to the spectral information on the unique vibrational states of individual molecules. Excellent sensitivity and reproducibility are dominantly derived from electric fields confined in dielectric media (i.e., hotspots) between plasmonic nanostructures, known as the localized surface plasmon resonance coupling. However, the clinical assays of infectious diseases using conventional SERS approaches are challenging due to the scale mismatch of hotspots to proteins and the signal loss from molecules adsorbed on nonplasㅎmonic areas. Although ligands have been exploited to capture target biomarkers in desired areas, these techniques involve issues such as time consumption for pretreatment, orientation, and nonspecific binding.

Then, I will explain 3D in-situ hotspot generation in the solution combining electrochemistry and Raman monitoring technique for rapid and label-free molecular detection. 3D hotspot engineering using electrochemistry has demonstrated great potential to reinforce SERS behaviors. In the classical electrochemical (EC)-SERS, surface roughening supports the LSPR effect while Fermi level adjustment of a metal electrode for the charge-transfer effect. To construct a novel concept of the 3D interior hotspot, a surface modification of biomolecules using an EC deposition of a metal layer can be considered.[3,4] Since a size of an analyte is directly proportional to that of a dielectric medium, an EC-SERS system is suitable for the trace of smaller molecules such as chemicals, DNAs and proteins.